2020年1月3日，加州环境健康危害评估办公室（OEHHA）将大麻烟雾和四氢大麻酚（THC）列入加州65清单。
 

序号	英文名	中文名	CAS号	毒理学特性	列入机制	生效日期
1	Cannabis (marijuana) smoke	大麻烟雾	-	生殖毒性	LC	2020.1.3
2	Δ9-Tetrahydrocannabinol (Δ9-THC)	四氢大麻酚（THC）	-	致癌性	LC	2020.1.3

注：LC-Labor Code 劳动法典。

2019年3月，加州环境健康危害评估办公室（OEHHA）收集了这2项物质具有生殖毒性的证据资料，并编写了文件。并且表明大麻的其他提取物可能以后会考虑。
 
2019年12月11日，发育和生殖毒性鉴定委员会（DARTIC）审议这些资料，以其“国家合格专家”（SQE）的官方身份确定：这2项物质具有致生殖和发育毒性的危害。
 
用途：数千年来，大麻在世界某些地区一直被用于医疗和精神治疗。A9-THC (delta-9-四氢大麻酚)被认为是大麻中最具精神活性的化合物。
 
危害：①大麻对生殖的可能影响：严重吸食大麻会降低男性睾丸激素的水平；②对婴儿的影响：如果孩子的母亲在怀孕期间吸食大麻，那么婴儿出生时可能会体重偏轻或早产。
 
美国加州65法案，全称《1986年饮用水安全和有毒物质强制执行法》，法案于1986年11月颁发，对加州境内的所有产品和环境进行监管，近几年，随着有害物质的受关注度越来越高，加州65法案清单中涉及的有害物质也已达约900项。
 
加州65法案要求，企业若使用了清单中的物质，则需要通过警示语的形式告知消费者危害信息，以帮助其在了解足够的信息后，合理消费。此外，2017年初，OEHHA发布新的警示语要求。

公告原文：

Chemicals Listed Effective January 3, 2020 As Known to The State of California To Cause Reproductive Toxicity (Developmental Endpoint): Cannabis (Marijuana) Smoke and Δ9-Tetrahydrocannabinol (Δ9-THC)

Jan 23, 2020
Effective January 3, 2020, the Office of Environmental Health Hazard Assessment is adding cannabis (marijuana) smoke and Δ9-tetrahydrocannabinol (Δ9-THC) to the list of chemicals known to the state to cause reproductive toxicity (developmental endpoint) for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65)[1]. At a public meeting on December 11, 2019, the Developmental and Reproductive Toxicant Identification Committee (DARTIC) in its official capacity as the “state’s qualified experts” determined that cannabis (marijuana) smoke and Δ9-tetrahydrocannabinol (Δ9-THC) were shown to cause reproductive toxicity based on the developmental endpoint. Regulations for the listing of chemicals by the DARTIC are set out in Title 27, California Code of Regulations, section 25305(b)(1).

What types of chemicals are on the Proposition 65 list?

The list contains a wide range of naturally occurring and synthetic chemicals that are known to cause cancer or birth defects or other reproductive harm. These chemicals include additives or ingredients in pesticides, common household products, food, drugs, dyes, or solvents. Listed chemicals may also be used in manufacturing and construction, or they may be byproducts of chemical processes, such as motor vehicle exhaust. Learn how chemicals are added to the list.